The main purpose of this present investigation is to develop de novo extended release system which can be easily administered by oral passage route and to compare with this with our controlled system (A4). In-vitro release data were obtained for each formulation using the dissolution apparatus (type I) at 50 rpm in 6.8 pH phosphate buffer. The extended release of drug from this formulation is superior and is able to maintain the release for almost 11 hours. An extended release rate developed using percent absorbed data and percent dissolved data from the formulation (A1, A2, A3 and A4). However HPMC proves a better and effective polymer and with increase in concentration by wet granulation technique the extendation of drug from HPMC matrixes also increases. This aspirin granule also exerts a good micromeritics property which is important for granules. Release kinetics of aspirin granules shows the zero order kinetics.
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